Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | HCID 57842645 | HCID 57842645 | — |
| Reactant | HCID 57842901 | HCID 57842901 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57842770 | HCID 57842770 | — |
Reaction Steps
EDCI (67 mg, 0.35 mmol), HOAt (80 mg, 0.58 mmol) and triethylamine (0.79 mL, 0.58 mmol) were added to a solution of 46C (100 mg, 0.3 mmol) and 16D (67 mg, 0.3 mmol) and stirred at 50° C. for 4 h. The reaction mixture was diluted with EtOAc, washed with water, brine, dried over Na2SO4 and concentrated in vacuo. The crude oil was purified by flash chromatography (0% to 20% MeOH in CH2Cl2) to yield 46D as a yellow solid. MS (ESI) m/z 535.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07592331B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
|---|
| ORD ID | ord-8b8efddf5b3d4a1686f57dd4a9d6584a |
|---|
| Source note | uspto-grants-2009_09 |
|---|
