HRID735626

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15620607

Oxoacetic acid--water (1/1)

C2H4O4

结构：Cc1cc(B(O)O)cc(C)c1CCO[Si](C)(C)C(C)(C)C

HCID57842550

未命名化合物

结构：CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nccc2cc(N)ccc12

HCID58717298

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C(Nc2ccc3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc3c2)C(=O)O)cc(C)c1CCO

HCID57842735

未命名化合物

收率 39%

PROCEDURE

实验过程

Using a procedure analogous to that used to prepare 2D, 50B (1.43 g, 4.6 mmol) was reacted with Intermediate 1 and glyoxylic acid monohydrate to afford 50C (1.1 g, 39%) as an orange solid. MS (ESI) m/z 566.6 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5ffcc14246f94e7899cf9bd1170cd1aa
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

[Si]([O:8][CH2:9][CH2:10][C:11]1[C:16]([CH3:17])=[CH:15][C:14](B(O)O)=[CH:13][C:12]=1[CH3:21])(C(C)(C)C)(C)C.[NH2:22][C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[C:29]([N:33]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])=[N:28][CH:27]=[CH:26]2.O.[C:49]([OH:53])(=[O:52])[CH:50]=O>>[C:44]([O:43][C:41]([N:33]([C:34]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:35])[C:29]1[C:30]2[C:25](=[CH:24][C:23]([NH:22][CH:50]([C:14]3[CH:13]=[C:12]([CH3:21])[C:11]([CH2:10][CH2:9][OH:8])=[C:16]([CH3:17])[CH:15]=3)[C:49]([OH:53])=[O:52])=[CH:32][CH:31]=2)[CH:26]=[CH:27][N:28]=1)=[O:42])([CH3:47])([CH3:46])[CH3:45]