HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (E)-4-(4-bromo-2,6-dimethylphenyl)but-2-enoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (E)-tert-butyl 4-(4-bromo-2,6-dimethylphenyl)but-2-enoate | HCID 57842697 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (E)-4-(4-bromo-2,6-dimethylphenyl)but-2-enoic acid | HCID 57842884 | 100.3% |
Reaction Steps
TFA (10 mL) was added to a solution of 53B (2.35 g) in CH2Cl2 (20 mL) at 0° C. and stirred for 4 h. The reaction mixture was concentrated to yield 53C (1.95 g, 99%) as an off-white solid. MS (ESI) m/z 267.2/269.2 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-7c342f08004640c786b4b2607ba7c13e |
| Source note | uspto-grants-2009_09 |