HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic acid, monohydrate → 2-(1-(Bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-(4-(3-cyanophenylamino)-4-oxobutyl)-3-methylphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 4-(4-(3-Cyanophenylamino)-4-oxobutyl)-3-methylphenylboronic acid | HCID 57842818 | — |
| Reactant | tert-butyl N-(6-aminoisoquinolin-1-yl)-N-[(tert-butoxy)carbonyl]carbamate | HCID 58717298 | — |
| Product | 2-(1-(Bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-(4-(3-cyanophenylamino)-4-oxobutyl)-3-methylphenyl)acetic acid | HCID 57842574 | 46% |
Reaction Steps
Using a procedure analogous to that used to prepare 2D, 55D (200 mg, 0.623 mmol) was reacted with Intermediate 1 and glyoxylic acid monohydrate to afford 55E (200 mg, 46%) as an oil. MS (ESI) m/z 694.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-01cff2f0e9dc421c9b58a81052c800c5 |
| Source note | uspto-grants-2009_09 |