HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminobenzamide → 2-(3-Carbamoylphenylamino)-2-(4-(2-(3-(3-cyanophenyl)-1-methylureido)ethyl)phenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminobenzamide | HCID 1645 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 4-(2-(3-(3-Cyanophenyl)-1-methylureido)ethyl)phenylboronic acid | HCID 57842610 | — |
| Product | 2-(3-Carbamoylphenylamino)-2-(4-(2-(3-(3-cyanophenyl)-1-methylureido)ethyl)phenyl)acetic acid | HCID 57842577 | 64% |
Reaction Steps
Using a procedure analogous to that used to prepare 2D, 23D (170 mg, 0.52 mmol) was reacted with 3-aminobenzamide and glyoxylic acid monohydrate to afford 58A (157 mg, 64%) as an oil. MS (ESI) m/z 472.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592331B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-5a03452fac2b4226b0a02d195bbb4033 |
| Source note | uspto-grants-2009_09 |