3-Aminobenzamide → HCID 57842878, compound

HRID 735672Notes

Reaction equation

HRID 735672 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([C:14]1[CH:15]=[C:16]([NH:20][C:21]([O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][C:27]=2[CH3:35])=[O:22])[CH:17]=[CH:18][CH:19]=1)[CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:36][C:37]1[CH:38]=[C:39]([CH:43]=[CH:44][CH:45]=1)[C:40]([NH2:42])=[O:41].O.[C:47]([OH:51])(=[O:50])[CH:48]=O>>[CH2:1]([O:8][C:9]([NH:11][C@@H:12]([C:14]1[CH:15]=[C:16]([NH:20][C:21]([O:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][C:29]([CH:48]([NH:36][C:37]3[CH:45]=[CH:44][CH:43]=[C:39]([C:40](=[O:41])[NH2:42])[CH:38]=3)[C:47]([OH:51])=[O:50])=[CH:28][C:27]=2[CH3:35])=[O:22])[CH:17]=[CH:18][CH:19]=1)[CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 16453-AminobenzamideHCID 15620607Glyoxylic acid, monohydrateHCID 57842816HCID 57842816, compound

Product 1

HCID 57842878HCID 57842878, compoundYield 70%

Procedure

Using a procedure analogous to that used to prepare 2D, 64D (175 mg, 0.37 mmol) was reacted with 3-aminobenzamide and glyoxylic acid monohydrate to afford 64E (175 mg, 70%) as an oil. MS (ESI) m/z 625.3 (M+H)+.

Sources & evidence

ORD record
ord-d7f202822ddd4d89a26655a7e384e476
Source dataset
uspto-grants-2009_09
Patent number
US07592331B2

Reaction notes

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