反应详情

温度

0 °C

To a solution of 3-(3-nitropyridin-4-yl)cyclohex-2-enone (1.0 equiv.) was added EtOH (1.1M) and CeCl3-7H2O (1.3 equiv.). The reaction was cooled to 0° C., then NaBH4 (1.3 equiv.) was added in portions. Stirred for 2 h at 0° C., then quenched by adding water, concentrated to remove the EtOH, added EtOAc, extracted the organics, dried with brine, then Na2SO4, and concentrated to yield 3-(3-nitropyridin-4-yl)cyclohex-2-enol (99%). LC/MS=221.1 (M+H), LC=2.24 min.

1. customquenched
2. additionby adding water
3. concentrationconcentrated
4. customto remove the EtOH
5. additionadded EtOAc
6. extractionextracted the organics,
7. dry with materialdried with brine
8. concentrationNa2SO4, and concentrated