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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 735699Generated: October 30, 2026

2-(1-(bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-((R)-1-hydroxypropan-2-yl)phenyl)-N-(3-nitrobenzyl)acetamide → N-(3-aminobenzyl)-2-(1-(bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-((R)-1-hydroxypropan-2-yl)phenyl)acetamide

https://huagongshe.com/reaction/735699

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(1-(bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-((R)-1-hydroxypropan-2-yl)phenyl)-N-(3-nitrobenzyl)acetamideHCID 57842665—
ReactantN-(3-Amino-benzyl)-2-(1-(bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-[4-(2-hydroxy-butyl)-phenyl]-acetamideHCID 57842720—
ProductN-(3-aminobenzyl)-2-(1-(bis(tert-butoxycarbonyl)amino)isoquinolin-6-ylamino)-2-(4-((R)-1-hydroxypropan-2-yl)phenyl)acetamideHCID 57842889—

Reaction Steps

76H (145 mg, 88%) was obtained from 76G (172 mg, 0.25 mmol) using a procedure similar to that used in the preparation of 70G. MS (ESI) m/z 656.4 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07592331B2
Source datasetuspto-grants-2009_09
ORD IDord-0009400aff9d49c99fc956b90d948458
Source noteuspto-grants-2009_09