HRID735703

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N(C(=O)OC(C)(C)C)c1nccc2cc(NC(C(=O)O)c3ccc(OCC(=O)Nc4cccc(CNC(=O)OCc5ccccc5)c4)cc3)ccc12

HCID57842637

未命名化合物

结构：CC(Cc1ccc(B(O)O)cc1)O[Si](C)(C)C(C)(C)C

HCID57842803

未命名化合物

PRODUCTS

生成物

结构：CC(Cc1ccc(C(Nc2ccc3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc3c2)C(=O)O)cc1)O[Si](C)(C)C(C)(C)C

HCID57842895

未命名化合物

收率 65%

PROCEDURE

实验过程

According to the procedure for the preparation of 66D, 77C (200 mg, 0.68 mmol) afforded 295 mg (65%) of 77D as an off-white solid. MS (ESI) m/z 666.4(M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd0f829b48c84d47b591339ab8bfe9c3
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

C(OC(NCC1C=C(NC(=O)COC2C=CC([CH:29]([NH:33][C:34]3[CH:35]=[C:36]4[C:41](=[CH:42][CH:43]=3)[C:40]([N:44]([C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[C:45]([O:47][C:48]([CH3:51])([CH3:50])[CH3:49])=[O:46])=[N:39][CH:38]=[CH:37]4)[C:30]([OH:32])=[O:31])=CC=2)C=CC=1)=O)C1C=CC=CC=1.[Si:60]([O:67][CH:68]([CH3:79])[CH2:69][C:70]1[CH:75]=[CH:74][C:73](B(O)O)=[CH:72][CH:71]=1)([C:63]([CH3:66])([CH3:65])[CH3:64])([CH3:62])[CH3:61]>>[C:48]([O:47][C:45]([N:44]([C:52]([O:54][C:55]([CH3:58])([CH3:56])[CH3:57])=[O:53])[C:40]1[C:41]2[C:36](=[CH:35][C:34]([NH:33][CH:29]([C:73]3[CH:74]=[CH:75][C:70]([CH2:69][CH:68]([O:67][Si:60]([C:63]([CH3:64])([CH3:66])[CH3:65])([CH3:61])[CH3:62])[CH3:79])=[CH:71][CH:72]=3)[C:30]([OH:32])=[O:31])=[CH:43][CH:42]=2)[CH:37]=[CH:38][N:39]=1)=[O:46])([CH3:50])([CH3:51])[CH3:49]