HRID735706

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC(O)Cc1ccc(C(Nc2ccc3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc3c2)C(=O)NCc2cccc(N)c2)cc1

HCID57842720

未命名化合物

结构：CC(O)Cc1ccc(C(Nc2ccc3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc3c2)C(=O)NCc2cccc([N+](=O)[O-])c2)cc1

HCID57842733

未命名化合物

PRODUCTS

生成物

结构：CC(O)Cc1ccc(C(Nc2ccc3c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc3c2)C(=O)NCc2cccc(N)c2)cc1

HCID57842727

未命名化合物

收率 80%

PROCEDURE

实验过程

According to the procedure for the preparation of 70G, 77F (38 mg, 0.055 mmol) afforded 29 mg (80%) of 77G as a white solid. MS (ESI) m/z 656.5 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-37b724de01204a57b3c8c63b5177bff2
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([CH:47]=[CH:48][CH:49]=1)[CH2:5][NH:6][C:7](=[O:46])[CH:8]([NH:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[C:27]([N:31]([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[N:26][CH:25]=[CH:24]2)[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([OH:19])[CH2:17]C)=[CH:11][CH:10]=1.C(OC(N(C(OC(C)(C)C)=O)C1C2C(=CC(NC(C3C=CC(CC(O)C)=CC=3)C(NCC3C=CC=C([N+]([O-])=O)C=3)=O)=CC=2)C=CN=1)=O)(C)(C)C>>[NH2:1][C:2]1[CH:3]=[C:4]([CH:47]=[CH:48][CH:49]=1)[CH2:5][NH:6][C:7](=[O:46])[CH:8]([NH:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[C:27]([N:31]([C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[C:32]([O:34][C:35]([CH3:37])([CH3:38])[CH3:36])=[O:33])=[N:26][CH:25]=[CH:24]2)[C:9]1[CH:10]=[CH:11][C:12]([CH2:15][CH:16]([OH:19])[CH3:17])=[CH:13][CH:14]=1