HRID735710

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCS(=O)(=O)c1ccc(NC(=O)COc2c(C)cc(C(Nc3ccc4c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc4c3)C(=O)O)cc2C)cc1CNC(=O)OCc1ccccc1

HCID57842813

未命名化合物

PRODUCTS

生成物

结构：CCS(=O)(=O)c1ccc(NC(=O)COc2c(C)cc(C(Nc3ccc4c(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)nccc4c3)C(=O)O)cc2C)cc1CN

HCID57842785

未命名化合物

收率 93%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 79D (190 mg, 0.205 mmol) in 5 mL methanol, was added 10% Pd—C (30 mg). The reaction was evacuated and flushed with H2 (3×), then stirred under an atmosphere of H2 for 1 h. The reaction was filtered and concentrated to afford 151 mg (93%) of 79E as an orange solid. MS (ESI) m/z 926.5 (M+H)+.

WORKUP

后处理

customThe reaction was evacuated
customflushed with H2 (3×)
filtrationThe reaction was filtered
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3e7e8457d4b4404d928cbacdbc97a102
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592331B2
来源说明: uspto-grants-2009_09

反应 SMILES

C(OC([NH:11][CH2:12][C:13]1[CH:14]=[C:15]([NH:24][C:25](=[O:66])[CH2:26][O:27][C:28]2[C:33]([CH3:34])=[CH:32][C:31]([CH:35]([NH:39][C:40]3[CH:41]=[C:42]4[C:47](=[CH:48][CH:49]=3)[C:46]([N:50]([C:58]([O:60][C:61]([CH3:64])([CH3:63])[CH3:62])=[O:59])[C:51]([O:53][C:54]([CH3:57])([CH3:56])[CH3:55])=[O:52])=[N:45][CH:44]=[CH:43]4)[C:36]([OH:38])=[O:37])=[CH:30][C:29]=2[CH3:65])[CH:16]=[CH:17][C:18]=1[S:19]([CH2:22][CH3:23])(=[O:21])=[O:20])=O)C1C=CC=CC=1>CO.[Pd]>[NH2:11][CH2:12][C:13]1[CH:14]=[C:15]([NH:24][C:25](=[O:66])[CH2:26][O:27][C:28]2[C:29]([CH3:65])=[CH:30][C:31]([CH:35]([NH:39][C:40]3[CH:41]=[C:42]4[C:47](=[CH:48][CH:49]=3)[C:46]([N:50]([C:58]([O:60][C:61]([CH3:64])([CH3:63])[CH3:62])=[O:59])[C:51]([O:53][C:54]([CH3:55])([CH3:57])[CH3:56])=[O:52])=[N:45][CH:44]=[CH:43]4)[C:36]([OH:38])=[O:37])=[CH:32][C:33]=2[CH3:34])[CH:16]=[CH:17][C:18]=1[S:19]([CH2:22][CH3:23])(=[O:21])=[O:20]