Phenethyl isocyanate → HCID 57846877, compound

HRID 735783Notes

Reaction equation

Cl.Cl.[C:3]1([C@@H:9]2[C@@H:18]3[CH2:19][CH2:20][N:21]([C:22]([C@H:24]4[CH2:29][CH2:28][CH2:27][CH2:26][NH:25]4)=[O:23])[C@@H:17]3[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[NH:10]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:30]([N:38]=[C:39]=[O:40])[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[C:32]1([CH2:31][CH2:30][NH:38][C:39]([N:25]2[CH2:26][CH2:27][CH2:28][CH2:29][C@@H:24]2[C:22]([N:21]2[C@@H:17]3[C@@H:18]([C@H:9]([C:3]4[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=4)[NH:10][C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=43)[CH2:19][CH2:20]2)=[O:23])=[O:40])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

Reactant 2

HCID 160602Phenethyl isocyanate

HCID 67150453HCID 67150453, compound

Product 1

HCID 57846877HCID 57846877, compound

Procedure

In the same manner as in Example 135 and using (3aS,4S,9bS)-4-phenyl-1-[(2R)-piperidin-2-ylcarbonyl]-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline dihydrochloride and phenethylisocyanate, the title compound was synthesized.

Sources & evidence

ORD record: ord-226b8f5cf01b4c9ab31e2ee4bff3978f
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07592453B2

Reaction notes

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