HRID735821

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81746

N-Methyldodecylamine

C13H29N

结构：CCOC(=O)C(=O)N(Cc1ccc(C(=O)O)cc1)Cc1ccc(C(F)(F)F)cc1

HCID67187953

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCN(C)C(=O)c1ccc(CN(Cc2ccc(C(F)(F)F)cc2)C(=O)C(=O)OCC)cc1

HCID67186466

未命名化合物

收率 56%

PROCEDURE

实验过程

The same procedure as employed in the preparation of Example 5, step d, but using 4-({[ethoxy(oxo)acetyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoic acid and dodecyl-methyl-amine gave the title compound as a colorless oil (56%). HPLC (Condition A), Rt: 7.41 min (HPLC purity: 82%).

WORKUP

后处理

customThe same procedure as employed in the preparation of Example 5, step d

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce104a995e9c4d0c9a2eec671847d321
来源数据集: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07592477B2
来源说明: uspto-grants-2009_09

反应 SMILES

[CH2:1]([O:3][C:4](=[O:29])[C:5]([N:7]([CH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=1)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)=[O:6])[CH3:2].[CH2:30]([NH:42][CH3:43])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>>[CH2:1]([O:3][C:4](=[O:29])[C:5]([N:7]([CH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([N:42]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[CH3:43])=[O:25])=[CH:22][CH:21]=1)[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([F:18])([F:16])[F:17])=[CH:13][CH:14]=1)=[O:6])[CH3:2]