N-Methyl-1-dodecanamine → HCID 67186466, compound

HRID 735821Notes

Reaction equation

HRID 735821 reaction equation
[CH2:1]([O:3][C:4](=[O:29])[C:5]([N:7]([CH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=1)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)=[O:6])[CH3:2].[CH2:30]([NH:42][CH3:43])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>>[CH2:1]([O:3][C:4](=[O:29])[C:5]([N:7]([CH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([N:42]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])[CH3:43])=[O:25])=[CH:22][CH:21]=1)[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([F:18])([F:16])[F:17])=[CH:13][CH:14]=1)=[O:6])[CH3:2]

Participants

3

Reactant 2

HCID 81746N-Methyl-1-dodecanamineHCID 67187953HCID 67187953, compound

Product 1

HCID 67186466HCID 67186466, compoundYield 56%

Procedure

The same procedure as employed in the preparation of Example 5, step d, but using 4-({[ethoxy(oxo)acetyl][4-(trifluoromethyl)benzyl]amino}methyl)benzoic acid and dodecyl-methyl-amine gave the title compound as a colorless oil (56%). HPLC (Condition A), Rt: 7.41 min (HPLC purity: 82%).

Workup

  1. customThe same procedure as employed in the preparation of Example 5, step d

Sources & evidence

ORD record
ord-ce104a995e9c4d0c9a2eec671847d321
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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