HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4'-(Aminomethyl)-biphenyl-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-(3-Tert-butoxy carbonyl phenyl)benzyl bromide | HCID 18398674 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4'-(Aminomethyl)-biphenyl-3-carboxylic acid | HCID 22311038 | — |
Reaction Steps
Ammonia gas was passed through a cooled solution of 4-(3-tert-butoxycarbonylphenyl) benzyl bromide (65 g, 0.18 mol) in methanol (2 L) for 6 h. Then the reaction mixture was stirred at RT overnight. Methanol was removed under vacuum. To the residue 6N aqueous solution of HCl (200 mL) was added and stirred overnight. Concentrated completely to get 4-(3-carboxyphenyl)benzylamine as a hydrochloride salt (20 g, 41%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592477B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-4151176dd32046dda93891a3c54c36b4 |
| Source note | uspto-grants-2009_09 |