4-(Trifluoromethyl)benzaldehyde → HCID 69003572, compound

HRID 735866Notes

Reaction equation

HRID 735866 reaction equation
[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[C:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][NH2:21])=[CH:16][CH:15]=2)=[CH:3][CH:2]=1.[F:22][C:23]([F:33])([F:32])[C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1>>[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[C:4]([C:14]2[CH:15]=[CH:16][C:17]([CH2:20][NH:21][CH2:28][C:27]3[CH:26]=[CH:25][C:24]([C:23]([F:22])([F:32])[F:33])=[CH:31][CH:30]=3)=[CH:18][CH:19]=2)=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 67186774HCID 67186774, compound

Product 1

HCID 69003572HCID 69003572, compoundYield 51%

Procedure

The same procedure as employed in the preparation of Example 1 (step a) using 1-(4-dibenzo[b,d]furan-4-ylphenyl)methanamine and 4-(trifluoromethyl)benzaldehyde gave the title compound (51%). M+(LC/MS(ESI)): 432.4

Workup

  1. customThe same procedure as employed in the preparation of Example 1 (step a)

Sources & evidence

ORD record
ord-7158ea4057024e2ca9422bdb405caa07
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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