Hydrochloric Acid → HCID 67188291, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[(dodecylamino)carbonyl]benzylcarbamate (2.35 g) in DCM (30 mL) was added a HCl solution (4N in dioxane, 30 mL). The resulting mixture was stirred at rt for 1 h. Evaporation of the solvents gave 4-(aminomethyl)-N-dodecylbenzamide hydrochloride compound as a white powder (1.97 g, 98%). M+(LC/MS(ESI)): 319.4; M−(LC/MS(ESI)): 317.4. HPLC (Condition A), Rt: 4.20 min (HPLC purity: 100%). 1H NMR (DMSO-d6, 300 MHz) δ 8.52 (br s, 3H), 7.87 (d, J=7.5 Hz, 2H), 7.56 (d, J=7.5 Hz, 2H), 4.06 (br s, 2H), 3.25-3.30 (m, 2H), 1.45-1.55 (m, 2H), 1.30-1.56 (m, 18H), 0.84 (t, J=8.3 Hz, 3H).

Provenance & Evidence