N-Methyl-D-glucamine → HCID 69000230, compound

HRID 735881Notes

Reaction equation

[O:1]=[C:2]([N:6]([CH:30]([C:32]1[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][CH:33]=1)[CH3:31])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[O:18][N:17]=[C:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[N:15]=2)=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4].[CH3:42][NH:43][CH2:44][C@@H:45]([C@H:47]([C@@H:49]([C@@H:51]([CH2:53][OH:54])[OH:52])[OH:50])[OH:48])[OH:46]>>[CH3:42][NH:43][CH2:44][C@@H:45]([C@H:47]([C@@H:49]([C@@H:51]([CH2:53][OH:54])[OH:52])[OH:50])[OH:48])[OH:46].[O:1]=[C:2]([N:6]([CH:30]([C:32]1[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][CH:33]=1)[CH3:31])[CH2:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2[O:18][N:17]=[C:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[N:15]=2)=[CH:12][CH:13]=1)[C:3]([OH:5])=[O:4]

Participants

Reactant 2

HCID 8567N-Methyl-D-glucamine

HCID 16040814HCID 16040814, compound

Product 1

HCID 69000230HCID 69000230, compoundYield 99%

Procedure

The same procedure as employed in the preparation of Example 2 using oxo{{1-[4-(trifluoromethyl)phenyl]ethyl}[4-(3-undecyl-1,2,4-oxadiazol-5-yl)benzyl]amino}acetic acid and N-methyl-D-glucamine gave the title compound as a white powder (99%). M−(LC/MS(ESI)): 572.5. HPLC (Condition A), Rt: 6.90 min (HPLC purity: 99.4%).

Sources & evidence

ORD record: ord-05df742507e041858a099b849755dc80
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07592477B2

Reaction notes

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