4-(Trifluoromethyl)benzylamine → HCID 67186177, compound

HRID 735886Notes

Reaction equation

HRID 735886 reaction equation
[C:1]([C:4]1[CH:24]=[CH:23][C:7]([C:8]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:9])=[CH:6][CH:5]=1)(=O)[CH3:2].[F:25][C:26]([F:36])([F:35])[C:27]1[CH:34]=[CH:33][C:30]([CH2:31][NH2:32])=[CH:29][CH:28]=1>>[CH2:11]([NH:10][C:8](=[O:9])[C:7]1[CH:23]=[CH:24][C:4]([CH:1]([NH:32][CH2:31][C:30]2[CH:29]=[CH:28][C:27]([C:26]([F:25])([F:35])[F:36])=[CH:34][CH:33]=2)[CH3:2])=[CH:5][CH:6]=1)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

3

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 67186598HCID 67186598, compound

Product 1

HCID 67186177HCID 67186177, compoundYield 71%

Procedure

The same procedure as employed in the preparation of Example 223 (step b) but using 4-acetyl-N-dodecylbenzamide and 4-(trifluoromethyl)benzylamine gave the title compound as a colorless oil (71%). M−(LC/MS(ESI)): 489.1; M+(LC/MS(ESI)): 491.5. HPLC (Condition A), Rt: 5.51 min (HPLC purity: 50.0%).

Workup

  1. customThe same procedure as employed in the preparation of Example 223 (step b)

Sources & evidence

ORD record
ord-c707ee6b521d412d89a4b4815c366870
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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