4-Nitrobenzylamine → HCID 67186505, compound

HRID 735891Notes

Reaction equation

[CH:1]1([C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N+:18]([C:21]1[CH:28]=[CH:27][C:24]([CH2:25][NH2:26])=[CH:23][CH:22]=1)([O-:20])=[O:19]>>[CH:1]1([CH:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[NH:26][CH2:25][C:24]2[CH:23]=[CH:22][C:21]([N+:18]([O-:20])=[O:19])=[CH:28][CH:27]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 291474-Nitrobenzylamine

HCID 24724174Cyclopentyl 4-trifluoromethylphenyl ketone

Product 1

HCID 67186505HCID 67186505, compoundYield 67%

Procedure

The same procedure as employed in the preparation of Example 223 (step b) but using cyclopentyl[4-(trifluoromethyl)phenyl]methanone and 4-nitrobenzylamine gave the title compound as an oil (67%). M−(LC/MS(ESI)): 377.2; M+(LC/MS(ESI)): 379.2

Workup

customThe same procedure as employed in the preparation of Example 223 (step b)

Sources & evidence

ORD record: ord-39ca2a5f3e384ae49656b4ca316923b8
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07592477B2

Reaction notes

Loading…