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4-Formylbenzoic acid → 4-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Formylbenzoic acid | HCID 12088 | — |
| 反応物 | N'-hydroxynonanimidamide | HCID 5074022 | — |
| 生成物 | 4-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde | HCID 86598532 | 34% |
反応手順
The same procedure as employed in the preparation of Example 277 (step a) but using 4-carboxybenzaldehyde and N-hydroxynonanimidamide gave the title compound as a beige solid (34%). 1H NMR (CDCl3, 300 MHz) δ 10.1 (s, 1H), 8.29 (d, 2H, J=8.3 Hz), 8.03 (d, 2H, J=8.3 Hz), 2.81 (t, 2H, J=7.4 Hz), 1.86-1.75 (m, 2H), 1.46-1.21 (m, 10H), 0.87 (m, 3H). HPLC (Condition A), Rt: 5.16 min (HPLC purity: 95.4%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592477B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-701c1f03980241c7ad958d767f09c87a |
| 出典メモ | uspto-grants-2009_09 |