HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorophenethylamine → N-[2-(3-chlorophenyl)ethyl]-N-[4-(3-octyl-1,2,4-oxadiazol-5-yl)benzyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorophenethylamine | HCID 139381 | — |
| Reactant | 4-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde | HCID 86598532 | — |
| Product | N-[2-(3-chlorophenyl)ethyl]-N-[4-(3-octyl-1,2,4-oxadiazol-5-yl)benzyl]amine | HCID 67186205 | 76% |
Reaction Steps
The same procedure as employed in the preparation of Example 226 (step a) but using 4-(3-octyl-1,2,4-oxadiazol-5-yl)benzaldehyde and [2-(3-chlorophenyl)ethyl]amine gave the title compound as a colorless oil (76%). 1H NMR (CDCl3, 300 MHz) δ 8.06 (d, J=8.3 Hz, 2H), 7.44 (d, J=8.3 Hz, 2H), 7.23-7.00 (m, 4H), 3.88 (s, 2H), 2.95-2.68 (m, 6H), 1.75-1.65 (m, 2H), 1.41-1.20 (m, 10H), 0.87 (t, J=7.1 Hz, 3H). M+(LC/MS(ESI)): 426.4. HPLC (Condition A), Rt: 4.35 min (HPLC purity: 99.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592477B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-627228f65be644dca881afb4fb010460 |
| Source note | uspto-grants-2009_09 |