Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Difluorobenzamide → 2,6-Difluorobenzene-1-carbothioamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Difluorobenzamide | HCID 87439 | — |
| 반응물 | Lawesson's reagent | HCID 87949 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2,6-Difluorobenzene-1-carbothioamide | HCID 12683212 | 99% |
반응 단계
A solution of 2, 6 difluorobenzamide (1 eq) and Lawesson's reagent (0.5 eq.) in toluene (0.2 M) was heated at 90° C. for 14 hours. Upon cooling the volatiles were removed in vacuo and purified by SiO2 chromatography (25% EtOAc/hexanes) yielding 2,6-difluorobenzothioamide as a light yellow solid (99%). LCMS (m/z): 174.1 (MH+); LC Rt=2.19 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829193B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b0b6e2c6e1cd425cb1c695a43492eb1a |
| 출처 메모 | uspto-grants-2014_09 |