3-(Trifluoromethyl)benzylamine → HCID 67188580, compound

HRID 735972Notes

Reaction equation

HRID 735972 reaction equation
[CH2:1]([C:12]1[N:16]=[C:15]([C:17]2[CH:24]=[CH:23][C:20]([CH:21]=O)=[CH:19][CH:18]=2)[O:14][N:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[F:25][C:26]([F:36])([F:35])[C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH2:30][NH2:31]>>[F:25][C:26]([F:35])([F:36])[C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH2:30][NH:31][CH2:21][C:20]1[CH:23]=[CH:24][C:17]([C:15]2[O:14][N:13]=[C:12]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[N:16]=2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 865985314-(3-Undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde

Product 1

HCID 67188580HCID 67188580, compound

Procedure

The same procedure as employed in the preparation of Example 357 (step a) but using 4-(3-undecyl-1,2,4-oxadiazol-5-yl)benzaldehyde and 3-(trifluoromethyl)benzylamine gave the title compound as an oil. M+(LC/MS(ESI)): 488.4. HPLC (Condition A), Rt: 4.84 min (HPLC purity: 64.4%).

Workup

  1. customThe same procedure as employed in the preparation of Example 357 (step a) but

Sources & evidence

ORD record
ord-f901e9c0ba454799b5d5da178a99394d
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

Loading…