4-((Trifluoromethyl)sulfonyl)benzylamine hydrochloride → N-{4-[(trifluoromethyl)sulfonyl]benzyl}-N-[4-(3-octyl-1,2,4-oxadiazol-5-yl)benzyl]amine

HRID 735980Notes

Reaction equation

HRID 735980 reaction equation
[CH2:1]([C:9]1[N:13]=[C:12]([C:14]2[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=2)[O:11][N:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl.[F:23][C:24]([F:37])([F:36])[S:25]([C:28]1[CH:35]=[CH:34][C:31]([CH2:32][NH2:33])=[CH:30][CH:29]=1)(=[O:27])=[O:26]>>[F:36][C:24]([F:23])([F:37])[S:25]([C:28]1[CH:35]=[CH:34][C:31]([CH2:32][NH:33][CH2:18][C:17]2[CH:20]=[CH:21][C:14]([C:12]3[O:11][N:10]=[C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[N:13]=3)=[CH:15][CH:16]=2)=[CH:30][CH:29]=1)(=[O:26])=[O:27]

Participants

3

Reactant 2

HCID 671882734-((Trifluoromethyl)sulfonyl)benzylamine hydrochlorideHCID 865985324-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde

Product 1

HCID 67186926N-{4-[(trifluoromethyl)sulfonyl]benzyl}-N-[4-(3-octyl-1,2,4-oxadiazol-5-yl)benzyl]amine

Procedure

The same procedure as employed in the preparation of Example 357 (step a) but using 4-(3-octyl-1,2,4-oxadiazol-5-yl)benzaldehyde and 4-[(trifluoromethyl)sulfonyl]benzylamine hydrochloride gave the title compound as an oil. HPLC (Condition A), Rt: 4.36 min (HPLC purity: 43.4%).

Workup

  1. customThe same procedure as employed in the preparation of Example 357 (step a) but

Sources & evidence

ORD record
ord-0c599682fc314389b2bcce4e68f8d748
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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