1,3-Benzodioxol-5-amine → N-1,3-benzodioxol-5-yl-N-[4-(3-octyl-1,2,4-oxadiazol-5-yl)benzyl]amine

HRID 735983Notes

Reaction equation

HRID 735983 reaction equation
[CH2:1]([C:9]1[N:13]=[C:12]([C:14]2[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=2)[O:11][N:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[O:22]1[C:26]2[CH:27]=[CH:28][C:29]([NH2:31])=[CH:30][C:25]=2[O:24][CH2:23]1>>[O:22]1[C:26]2[CH:27]=[CH:28][C:29]([NH:31][CH2:18][C:17]3[CH:20]=[CH:21][C:14]([C:12]4[O:11][N:10]=[C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[N:13]=4)=[CH:15][CH:16]=3)=[CH:30][C:25]=2[O:24][CH2:23]1

Participants

3

Reactant 2

HCID 843101,3-Benzodioxol-5-amineHCID 865985324-(3-Octyl-1,2,4-oxadiazol-5-yl)benzaldehyde

Product 1

HCID 67189429N-1,3-benzodioxol-5-yl-N-[4-(3-octyl-1,2,4-oxadiazol-5-yl)benzyl]amine

Procedure

The same procedure as employed in the preparation of Example 357 (step a) but using 4-(3-octyl-1,2,4-oxadiazol-5-yl)benzaldehyde and 1,3-benzodioxol-5-ylamine gave the title compound as an oil. M+(LC/MS(ESI)): 408.4. HPLC (Condition A), Rt: 4.54 min (HPLC purity: 85.5%).

Workup

  1. customThe same procedure as employed in the preparation of Example 357 (step a) but

Sources & evidence

ORD record
ord-a4dadc58a0644e8ea54c7706fada1240
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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