反应详情

A solution of 2,6-difluorobenzothioamide (1.0 eq) and ethylbromopyruvate (1.0 eq.) in ethanol (1.0 M) was heated in the microwave at 130° C. for 30 minutes. Upon removal of volatiles in vacuo, ethyl acetate was added and the solution was washed with Na2CO3(sat.), with NaCl(sat.), was dried over MgSO4, filtered and concentrated yielding ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate (84%). LCMS (m/z): 270.1 (MH+); LC Rt=3.79 min.

1. customUpon removal of volatiles in vacuo, ethyl acetate
2. additionwas added
3. washthe solution was washed with Na2CO3(sat.), with NaCl(sat.)
4. dry with materialwas dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated