2-(Trifluoromethyl)benzylamine → HCID 67186969, compound

HRID 735998Notes

Reaction equation

HRID 735998 reaction equation
[CH2:1]([O:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[F:18][C:19]([F:29])([F:28])[C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22][NH2:23]>>[CH2:1]([O:9][C:10]1[CH:17]=[CH:16][C:13]([CH2:14][NH:23][CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[C:19]([F:18])([F:28])[F:29])=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 764472-(Trifluoromethyl)benzylamineHCID 90358p-(Octyloxy)benzaldehyde

Product 1

HCID 67186969HCID 67186969, compound

Procedure

The same procedure as employed in the preparation of Example 394 (step b) but using 4-(octyloxy)benzaldehyde and 2-(trifluoromethyl)benzylamine gave the title compound as an oil. HPLC (Condition A), Rt: 4.24 min (HPLC purity: 91.0%).

Workup

  1. customThe same procedure as employed in the preparation of Example 394 (step b)

Sources & evidence

ORD record
ord-0036f493b9044a41a9c0d61bf231a82c
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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