HCID 67186375, compound → HCID 178442770, compound

HRID 736004Notes

Reaction equation

HRID 736004 reaction equation
[C:1]([C:11]1[CH:34]=[CH:33][C:14]([CH2:15][N:16]([C:28](=[O:32])[C:29]([OH:31])=[O:30])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:13][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[NH2:35][C@H:36]([C:44]([OH:46])=[O:45])[CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:43])[NH2:42]>>[NH2:35][C@H:36]([C:44]([OH:46])=[O:45])[CH2:37][CH2:38][CH2:39][NH:40][C:41](=[NH:42])[NH2:43].[C:1]([C:11]1[CH:34]=[CH:33][C:14]([CH2:15][N:16]([C:28](=[O:32])[C:29]([OH:31])=[O:30])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:13][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 67186375HCID 67186375, compoundHCID 178418600HCID 178418600, compound

Product 1

HCID 178442770HCID 178442770, compound

Procedure

The same procedure as employed in the preparation of Example 2 but using {(4-dec-1-ynylbenzyl)[4-(trifluoromethyl)benzyl]amino}(oxo)acetic acid and L-arginine gave the title compound as a white powder. M−(LC/MS(ESI)): 472.4. HPLC (Condition A), Rt: 5.55 min (HPLC purity 99.6%).

Workup

  1. customThe same procedure as employed in the preparation of Example 2

Sources & evidence

ORD record
ord-b4c12fd710f340a7b28df859569bb2bf
Source dataset
uspto-grants-2009_09
Patent number
US07592477B2

Reaction notes

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