Sodium Hydroxide → HCID 67188343, compound

HRID 736005Notes

Reaction equation

[C:1]([C:11]1[CH:34]=[CH:33][C:14]([CH2:15][N:16]([C:28](=[O:32])[C:29]([OH:31])=[O:30])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:13][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[OH-].[Na+:36]>>[C:1]([C:11]1[CH:34]=[CH:33][C:14]([CH2:15][N:16]([C:28](=[O:32])[C:29]([O-:31])=[O:30])[CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:13][CH:12]=1)#[C:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[Na+:36]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 67186375HCID 67186375, compound

Product 1

HCID 67188343HCID 67188343, compound

Procedure

The same procedure as employed in the preparation of Example 2 but using {(4-dec-1-ynylbenzyl)[4-(trifluoromethyl)benzyl]amino}(oxo)acetic acid and sodium hydroxide gave the title compound as a white solid. M−(LC/MS(ESI)): 472.2. HPLC (Condition A), Rt: 5.54 min (HPLC purity: 99.6%).

Workup

customThe same procedure as employed in the preparation of Example 2

Sources & evidence

ORD record: ord-1b4aaabafda84f2cb1b18755e47f2af6
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07592477B2

Reaction notes

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