2-Piperidone → 1-{2-[(1-Cyclopentylpiperidin-4-yl)oxy]pyrimidin-5-yl}piperidin-2-one

HRID 736044Notes

Reaction equation

HRID 736044 reaction equation
[CH:1]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[N:18]=[CH:17][C:16](Br)=[CH:15][N:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][C:21]1=[O:26]>>[CH:1]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[N:18]=[CH:17][C:16]([N:20]4[CH2:25][CH2:24][CH2:23][CH2:22][C:21]4=[O:26])=[CH:15][N:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 126652-PiperidoneHCID 231159615-Bromo-2-[(1-cyclopentylpiperidin-4-yl)oxy]pyrimidine

Product 1

HCID 231159721-{2-[(1-Cyclopentylpiperidin-4-yl)oxy]pyrimidin-5-yl}piperidin-2-one

Procedure

According to the same method as in Example 17 but using 2-(1-cyclopentylpiperidin-4-yloxy)-5-bromopyrimidine and piperidin-2-one, the entitled compound was obtained.

Workup

  1. customthe entitled compound was obtained

Sources & evidence

ORD record
ord-81080fc6d3fe41e6a3c877f4459305ec
Source dataset
uspto-grants-2009_09
Patent number
US07595316B2

Reaction notes

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