HCID 23115973, compound → HCID 11750164, compound

HRID 736045Notes

Reaction equation

HRID 736045 reaction equation
[CH:1]1([N:6]2[CH2:11][CH2:10][CH:9]([O:12][C:13]3[N:18]=[CH:17][C:16]([C:19]4[CH:20]=[CH:21][C:22]([O:25][CH2:26][C:27]5C=C[CH:30]=[CH:29][CH:28]=5)=[N:23][CH:24]=4)=[CH:15][N:14]=3)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>[C].[Pd].CO>[CH:1]1([N:6]2[CH2:7][CH2:8][CH:9]([O:12][C:13]3[N:14]=[CH:15][C:16]([C:19]4[CH:20]=[CH:21][C:22]([O:25][CH:26]5[CH2:27][CH2:28][CH2:29][CH2:30]5)=[N:23][CH:24]=4)=[CH:17][N:18]=3)[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 2

HCID 23115973HCID 23115973, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11750164HCID 11750164, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

10% palladium-carbon (700 mg) was added to a methanol solution (30 ml) of 2-(cyclopentylpiperidin-4-yloxy)-5-(2-benzyloxypyridin-5-yl)pyrimidine (2.22 g), and stirred in a hydrogen atmosphere at room temperature for 3 hours. The reaction mixture was filtered to remove palladium-carbon, and the filtrate was concentrated under reduced pressure to obtain the entitled compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customto remove palladium-carbon
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customto obtain the entitled compound

Sources & evidence

ORD record
ord-89926b296023487081e14fd3e496c29c
Source dataset
uspto-grants-2009_09
Patent number
US07595316B2

Reaction notes

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