4-Fluorobenzoyl chloride → HCID 66640395, compound

HRID 736049Notes

Reaction equation

HRID 736049 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:12]2[NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[C:18]([O:20][CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:19]=3[C:11]=2[CH2:10][CH2:9][NH:8][CH:7]=1)=[O:5])[CH3:2].[F:28][C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1.FC1C=C(C=CC=1F)C(Cl)=O>>[CH2:1]([O:3][C:4]([C:6]1[C:12]2[NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[C:18]([O:20][CH2:21][C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[C:19]=3[C:11]=2[CH2:10][CH2:9][N:8]([C:33](=[O:34])[C:32]2[CH:36]=[CH:37][C:29]([F:28])=[CH:30][CH:31]=2)[CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 678794-Fluorobenzoyl chlorideHCID 27245193,4-Difluorobenzoyl chlorideHCID 66640912HCID 66640912, compound

Product 1

HCID 66640395HCID 66640395, compound

Procedure

In a manner similar to Step A, but replacing ethyl 1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate with 10-benzyloxy-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylic acid ethyl ester and 4-fluorobenzoyl chloride with 3,4-difluorobenzoyl chloride, the following compound was prepared:

Workup

  1. customthe following compound was prepared

Sources & evidence

ORD record
ord-b6a1f22f229d424ba2447e387aba1484
Source dataset
uspto-grants-2009_09
Patent number
US07595311B2

Reaction notes

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