4-Fluorobenzoyl chloride → HCID 57559149, compound

HRID 736060Notes

Reaction equation

HRID 736060 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:12]2[NH:13][C:14]3[CH:15]=[CH:16][C:17]([Br:20])=[CH:18][C:19]=3[C:11]=2[CH2:10][CH2:9][NH:8][CH:7]=1)=[O:5])[CH3:2].[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:12]2[NH:13][C:14]3[CH:15]=[CH:16][C:17]([Br:20])=[CH:18][C:19]=3[C:11]=2[CH2:10][CH2:9][N:8]([C:26](=[O:27])[C:25]2[CH:29]=[CH:30][C:22]([F:21])=[CH:23][CH:24]=2)[CH:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 66640350HCID 66640350, compound

Product 1

HCID 57559149HCID 57559149, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using 9-bromo-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylic acid ethyl ester and 4-fluorobenzoyl chloride; 1H-NMR (CDCl3): δ 10.56 (1H, s), 7.98 (1H, s), 7.56 (3H, m), 7.19 (1H, m), 7.09 (2H, m), 4.17 (4H, m), 3.13 (2H, m), 1.13 (3H, t). MS (ESI): 457, 459 (MH+).

Sources & evidence

ORD record
ord-52136cb50f3746a59171dcc7955710b9
Source dataset
uspto-grants-2009_09
Patent number
US07595311B2

Reaction notes

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