HCID 57467944, compound → HCID 66640929, compound

HRID 736087Notes

Reaction equation

HRID 736087 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:12]2[NH:13][C:14]3[CH:15]=[C:16](OCC4C=CC=CC=4)[CH:17]=[CH:18][C:19]=3[C:11]=2[C:10](C)(C)[CH2:9][N:8]([C:30](=[O:38])[C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[CH:7]=1)=[O:5])[CH3:2].C([O:41]C(C1C2NC3C=CC(OCC4C=CC=CC=4)=CC=3C=2C(C)(C)CN(C(=O)C2C=CC(F)=CC=2)C=1)=O)C.C(OC(C1C2NC3C=CC(N(CC4C=CC=CC=4)CC4C=CC=CC=4)=CC=3C=2C(C)(C)CN(C(=O)C2C=CC(F)=CC=2)C=1)=O)C>>[CH2:1]([O:3][C:4]([C:6]1[C:12]2[NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[C:18]([OH:41])[C:19]=3[C:11]=2[CH2:10][CH2:9][N:8]([C:30](=[O:38])[C:31]2[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=2)[CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 57467944HCID 57467944, compoundHCID 57467954HCID 57467954, compoundHCID 66640229HCID 66640229, compound

Product 1

HCID 66640929HCID 66640929, compound

Procedure

In a manner similar to that described above in Step A, but replacing 7-benzyloxy-3-(4-fluorobenzoyl)-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylic acid ethyl ester with 8-benzyloxy-3-(4-fluorobenzoyl)1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylic acid ethyl ester, 9-benzyloxy-3-(4-fluorobenzoyl)1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylic acid ethyl ester or 9-dibenzylamino-3-(4-fluorobenzoyl)-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylic acid ethyl ester, the following compounds were prepared:

Workup

  1. customthe following compounds were prepared

Sources & evidence

ORD record
ord-25e5674700864ce38a65a4fd863d16bd
Source dataset
uspto-grants-2009_09
Patent number
US07595311B2

Reaction notes

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