4-Fluorobenzoyl chloride → HCID 57559106, compound

HRID 736104Notes

Reaction equation

HRID 736104 reaction equation
[CH3:1][NH:2][C:3]([CH:5]1[C:11]2[NH:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:10]=2[CH2:9][CH2:8][NH:7][CH2:6]1)=[O:4].[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[CH3:1][NH:2][C:3]([CH:5]1[C:11]2[NH:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:18]=3[C:10]=2[CH2:9][CH2:8][N:7]([C:24](=[O:25])[C:23]2[CH:27]=[CH:28][C:20]([F:19])=[CH:21][CH:22]=2)[CH2:6]1)=[O:4]

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 57559109HCID 57559109, compound

Product 1

HCID 57559106HCID 57559106, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using N-methyl 1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carbamide and 4-fluorobenzoyl chloride; 1H-NMR (CDCl3): δ 9.49 (1H, br s), 7.35 (3H, m), 7.24 (1H, m), 7.14 (4H, m), 4.30 (2H, m), 4.19 (1H, m), 3.69 (2H, m), 3.07 (1H, m), 2.91 (1H, m), 2.78 (3H, br s); MS (ES): 366.2 (MH+).

Sources & evidence

ORD record
ord-5784f761654b4cc9ac93fe8de2cbc4f6
Source dataset
uspto-grants-2009_09
Patent number
US07595311B2

Reaction notes

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