참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-benzyl-1H-indol-3-ylacetonitrile | HCID 11032169 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 1-(1-benzyl-1H-indol-3-yl)cyclopentanecarbonitrile | HCID 10709379 | — |
반응 단계
To a suspension of sodium hydride (60%, 2.26 g, 56 mmol) was added a solution of 1-benzyl-1H-indol-3-ylacetonitrile (5.7g, 22 mmol) and 1,4-dibrombutane (2.6 ml) in DMSO-ether (10 ml: 80 mL) dropwise and the mixture was stirred for 5 hours at 20° C. Water and hexane were added. Solid was collected by filtration and washed with water and hexane to give 1-(1-benzyl-1H-indol-3-yl)cyclopentanecarbonitrile (5.3 g). MS (ES): 301 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07595311B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_09 |
|---|
| ORD ID | ord-c3c6b2558d9c49f982469c255fda361a |
|---|
| 출처 메모 | uspto-grants-2009_09 |
|---|
