HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736116Generated: October 30, 2026
Thionyl Chloride → 2-Morpholin-4-yl-5-nitro-benzoyl chloride
https://huagongshe.com/reaction/736116
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Morpholino-5-nitrobenzoic acid | HCID 2725755 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Morpholin-4-yl-5-nitro-benzoyl chloride | HCID 17274153 | 93% |
Reaction Steps
To a suspension of 2-Morpholin-4-yl-5-nitro-benzoic acid (4.0 g, 16 mmol) in toluene were added 2 drops of DMF and thionylchloride (5.7 ml, 79.3 mmol). The mixture was heated to 80° C. for 50 minutes. The solvent was removed in vacuo, and the resulting solid was stirred in ether, filtered and dried to provide the title compound (4.0 g, 93%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07595314B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
|---|
| ORD ID | ord-3faa587248124bbda696d02b7895cb6d |
|---|
| Source note | uspto-grants-2009_09 |
|---|
