HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736118Generated: October 25, 2026
Trifluoroacetic acid → 1-[2-Chloro-4-(trifluoromethyl)phenyl]piperazine
https://huagongshe.com/reaction/736118
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(2-Chloro-4-trifluoromethylphenyl)piperazine-1-carboxylic acid tert-butyl ester | HCID 53485518 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[2-Chloro-4-(trifluoromethyl)phenyl]piperazine | HCID 46837496 | 46.1% |
Reaction Steps
A solution of 4-(2-Chloro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (60 mg, 0.164 mmol) in MeCl2 (0.8 ml) was treated with trifluoroacetic acid (63 μl), heated up to 40° C. and stirred for 4 h. The solvent was removed in vacuo. The residue was dissolved in water and basified with NaOH 1N. The aqueous layer was extracted twice with MeCl2. The combined organic layers were dried over Na2SO4, filtered and the solvent was removed in vacuo to provide the title compound (20 mg, 46%) as a yellow oil, MS (m/e): 265.0 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07595314B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-fc04aaddcbc847309408fe0dcaee7f44 |
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| Source note | uspto-grants-2009_09 |
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