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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736119Generated: October 29, 2026

2-Chloro-5-(trifluoromethyl)benzonitrile → Tert-butyl 4-[2-cyano-4-(trifluoromethyl)phenyl]piperazine-1-carboxylate

https://huagongshe.com/reaction/736119

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-(trifluoromethyl)benzonitrileHCID 67604—
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
ProductTert-butyl 4-[2-cyano-4-(trifluoromethyl)phenyl]piperazine-1-carboxylateHCID 5979368515%

Reaction Steps

Title compound was prepared according to the procedure described in example G from N-Boc-piperazine and 2-Chloro-5-trifluoromethylbenzonitrile (CAS: 328-87-0)(15% yield, yellow oil, MS (m/e): 373.1 (M+NH4+, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07595314B2
Source datasetuspto-grants-2009_09
ORD IDord-4b604ecdaf9047f4ac6dbeab0de8e4d1
Source noteuspto-grants-2009_09