Isopropylamine → 2-Chloro-5-[(propan-2-yl)sulfamoyl]benzoic acid

HRID 736139Notes

Reaction equation

HRID 736139 reaction equation
ClC1C=CC(S(=O)(=O)NC)=CC=1C(O)=O.[Cl:16][C:17]1[CH:25]=[CH:24][C:23]([S:26]([OH:28])=[O:27])=[CH:22][C:18]=1[C:19]([OH:21])=[O:20].[CH:29]([NH2:32])([CH3:31])[CH3:30]>>[Cl:16][C:17]1[CH:25]=[CH:24][C:23]([S:26](=[O:28])(=[O:27])[NH:32][CH:29]([CH3:31])[CH3:30])=[CH:22][C:18]=1[C:19]([OH:21])=[O:20]

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 151129042-Chloro-5-sulfino-benzoic acid

Product 1

HCID 9779142-Chloro-5-[(propan-2-yl)sulfamoyl]benzoic acidYield 74%

Procedure

The title compound was synthesised according to the procedure described for 2-Chloro-5-methylsulfamoyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and isopropylamine and obtained in 74% yield. MS (m/e): 276.1 (MH−, 100%).

Workup

  1. customobtained in 74% yield

Sources & evidence

ORD record
ord-a7119ea8ded84892942151cef786d5f2
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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