Morpholine → HCID 59793747, compound

HRID 736157Notes

Reaction equation

HRID 736157 reaction equation
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:35])(=[O:34])[NH:30][CH:31]([CH3:33])[CH3:32])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:36]1[CH2:41][CH2:40][O:39][CH2:38][CH2:37]1>>[CH:31]([NH:30][S:29]([C:26]1[CH:27]=[CH:28][C:20]([N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)=[C:21]([CH:25]=1)[C:22]([OH:24])=[O:23])(=[O:35])=[O:34])([CH3:33])[CH3:32]

Participants

4

Reactant 3

HCID 8083MorpholineHCID 9779142-Chloro-5-[(propan-2-yl)sulfamoyl]benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 59793747HCID 59793747, compoundYield 38%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-isopropylsulfamoyl-benzoic acid and morpholine and obtained in 38% yield. MS (m/e): 327.2 (MH−, 100%).

Workup

  1. customobtained in 38% yield

Sources & evidence

ORD record
ord-181bd91024f244c586a55b5a0dbc6986
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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