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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736176Generated: October 27, 2026

2-Morpholin-4-yl-5-nitro-benzoyl chloride → 2-(4-(2-Morpholino-5-nitrobenzoyl)piperazin-1-yl)-5-(trifluoromethyl)benzonitrile

https://huagongshe.com/reaction/736176

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Morpholin-4-yl-5-nitro-benzoyl chlorideHCID 17274153—
Reactant2-Piperazin-1-yl-5-trifluoromethyl-benzonitrileHCID 43153495—
Product2-(4-(2-Morpholino-5-nitrobenzoyl)piperazin-1-yl)-5-(trifluoromethyl)benzonitrileHCID 11156047—

Reaction Steps

The title compound was prepared according to the procedure described for example 46 from 2-piperazin-1-yl-5-trifluoromethyl-benzonitrile and 2-Morpholin-4-yl-5-nitro-benzoyl chloride (69%, yellow solid, MS (m/e): 490.2 (M+H, 100%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07595314B2
Source datasetuspto-grants-2009_09
ORD IDord-c53e787e918b4215abf8d0efb1347b50
Source noteuspto-grants-2009_09