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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736177Generated: October 25, 2026

1-Bromo-4-(methylsulphonyl)benzene → 4-(4-Methanesulfonyl-phenyl)piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/736177

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-4-(methylsulphonyl)benzeneHCID 77014—
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Product4-(4-Methanesulfonyl-phenyl)piperazine-1-carboxylic acid tert-butyl esterHCID 59793501—

Reaction Steps

The title compound was prepared according to the procedure described for example AX from 4-bromophenyl methyl sulfone and N-Boc-piperazine (31%, white solid, MS (m/e): 241.2 (M−Boc, 100%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07595314B2
Source datasetuspto-grants-2009_09
ORD IDord-9fe652b2e94f4b6a81352d98e255bda7
Source noteuspto-grants-2009_09