Morpholine → [4-(2-Fluoro-phenyl)-piperazin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

HRID 736184Notes

Reaction equation

HRID 736184 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([N:13]1[CH2:18][CH2:17][N:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[F:25])[CH2:15][CH2:14]1)=[O:12].[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[F:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[N:16]1[CH2:17][CH2:18][N:13]([C:11]([C:3]2[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=2[N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)=[O:12])[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 59793717(2-Fluoro-5-nitro-phenyl)[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

Product 1

HCID 59793722[4-(2-Fluoro-phenyl)-piperazin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

Procedure

The title compound was prepared according to the procedure described for example 1 from (2-Fluoro-5-nitro-phenyl)-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone and morpholine (87%, yellow solid, MS (m/e): 415.2 (M+H, 100%)

Sources & evidence

ORD record
ord-103ae9740140450d9f126af48842c0be
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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