Morpholine → 3-(4-(4-Acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzonitrile

HRID 736194Notes

Reaction equation

HRID 736194 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=3Br)[C:21]#[N:22])=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:27])[CH:5]=1)(=[O:3])[CH3:2].[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=3[N:28]3[CH2:33][CH2:32][O:31][CH2:30][CH2:29]3)[C:21]#[N:22])=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:27])[CH:5]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 597935213-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-bromo benzonitrile

Product 1

HCID 445805523-(4-(4-Acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzonitrile

Procedure

The title compound was prepared according to the procedure described for example 1 from 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-bromo-benzonitrile (example L) and morpholine (71%, white solid), MS (m/e): 437.2 (M+H, 100%)

Sources & evidence

ORD record
ord-1308f01283bd4b5d97cfbcd407145393
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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