Morpholine → 3-(4-(4-Acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

HRID 736197Notes

Reaction equation

HRID 736197 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3Cl)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:29])[CH:5]=1)(=[O:3])[CH3:2].[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([C:18]3[CH:19]=[C:20]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=3[N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)=[O:17])[CH2:12][CH2:11]2)=[C:6]([F:29])[CH:5]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 368074103-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-benzenesulfonamide

Product 1

HCID 417727443-(4-(4-Acetyl-2-fluorophenyl)piperazine-1-carbonyl)-4-morpholinobenzenesulfonamide

Procedure

The title compound was prepared according to the procedure described for example 1 from 3-[4-(4-Acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-chloro-benzenesulfonamide and morpholine (39%, yellow solid), MS (m/e): 489.4 (M−H, 100%)

Sources & evidence

ORD record
ord-7ae1e374a404431c8bd3f5be5e83d6de
Source dataset
uspto-grants-2009_09
Patent number
US07595314B2

Reaction notes

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