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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 736200Generated: October 25, 2026

tert-Butyl piperazine-1-carboxylate → 4-(2-Chloro-4-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/736200

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Reactant1-Bromo-2-chloro-4-fluorobenzeneHCID 2733406—
Product4-(2-Chloro-4-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl esterHCID 59793605—

Reaction Steps

The title compound was prepared according to the procedure described for example AX from 1-bromo-2-chloro-4-fluorobenzene and N-Boc-piperazine (10%, off white solid, MS (m/e): 315.1 (M+H, 100%)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07595314B2
Source datasetuspto-grants-2009_09
ORD IDord-eaebb2aff36149609cfb46c4bdae6a15
Source noteuspto-grants-2009_09