HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]- → Rac-2-(3-hydroxymethyl-pyrrolidin-1-yl)-5-methylsulfamoyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]- | HCID 111724 | — |
| Reactant | (Pyrrolidin-3-yl)methanol | HCID 13400657 | — |
| Reactant | 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid | HCID 59793489 | — |
| Product | Rac-2-(3-hydroxymethyl-pyrrolidin-1-yl)-5-methylsulfamoyl-benzoic acid | HCID 59793538 | 25% |
Reaction Steps
The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-methylsulfamoyl-benzoic acid and rac-pyrrolidin-3-yl-methanol and obtained in 25% yield. MS (m/e): 313.0 MH−(100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595314B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-4c7f7b038a574f4caca6b2389a97c8dc |
| Source note | uspto-grants-2009_09 |