HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 2-Pyrrolidin-1-yl-5-sulfamoyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Chloro-5-aminosulfonylbenzoic acid | HCID 66794 | — |
| Reactant | 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid | HCID 59793489 | — |
| Product | 2-Pyrrolidin-1-yl-5-sulfamoyl-benzoic acid | HCID 43217634 | 19% |
Reaction Steps
The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-sulfamoyl-benzoic acid (CAS: 97-04-1; Basu; D.-G.; J. Indian Chem. Soc.; 16; 1939; 100, 106) and pyrrolidine and obtained in 19% yield. MS (m/e): 269.4 (MH− 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07595314B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-3b3c99e5dba74698a5683b898f52b8ad |
| Source note | uspto-grants-2009_09 |