2-(4-Benzylpiperazin-1-yl)-5-trifluoromethylpyrimidine → 2-(Piperazin-1-YL)-5-(trifluoromethyl)pyrimidine

HRID 736227Notes

Reaction equation

C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO>[N:11]1([C:14]2[N:15]=[CH:16][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:18][N:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

Conditions

Temperature: 60 °C

Procedure

To a solution of 2-(4-Benzyl-piperazin-1-yl)-5-trifluoromethyl-pyrimidine (0.63 g) in methanol was added Palladium-C (Degussa EL101N; 5%) and the reaction mixture was heated at 60° C. under hydrogen atmosphere. The reaction mixture was then allowed to cool down to room temperature, the catalyst was filtered of and solvent was removed in vacuo to yield the title compound as a colorless solid (0.41 g). MS (m/e): 233.1 (M+H+).

Workup

temperatureto cool down to room temperature
filtrationthe catalyst was filtered of and solvent
customwas removed in vacuo

Sources & evidence

ORD record: ord-fbbf7bc8f662401c9aab097c9dcff3a4
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595314B2

Reaction notes

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